trkA Receptor

A protein-tyrosine kinase receptor that is specific for NERVE GROWTH FACTOR; NEUROTROPHIN 3; neurotrophin 4, neurotrophin 5. It plays a crucial role in pain sensation and thermoregulation in humans. Gene mutations that cause loss of receptor function are associated with CONGENITAL INSENSITIVITY TO PAIN WITH ANHIDROSIS, while gene rearrangements that activate the protein-tyrosine kinase function are associated with tumorigenesis.

Also Known As:

Receptor, trkA; Neurotrophic Tyrosine Kinase Receptor Type 1; Proto-Oncogene Products c-trk; c-trk Protein; gp140 c-trk; p140-trkA; trk1 Transforming Tryrosine Kinase; Proto Oncogene Products c trk; Proto Oncogene Protein trk; Proto-Oncogene Protein, trk; Receptor, NTRK1; c trk Protein; c-trk, Proto-Oncogene Products; c-trk, gp140; gp140 c trk; p140 trkA; trk Proto Oncogene Protein; trk, Proto-Oncogene Protein; NTRK1 Receptor; Proto-Oncogene Protein trk; Receptor, Neurotrophic Tyrosine Kinase Type 1; gp140(c-TRK); trk Proto-Oncogene Protein

Enzymes and Coenzymes: 1
- Enzymes: 155591
  - Transferases: 6719
    - Phosphotransferases: 43773
      - Phosphotransferases (Alcohol Group Acceptor)
        Protein Kinases: 9899
        Protein-Tyrosine Kinases: 7827
        Receptor Protein-Tyrosine Kinases: 6127
        trkA Receptor: 145
Amino Acids, Peptides, and Proteins: 1
- Proteins: 496323
  - Membrane Proteins: 10262
    - Cell Surface Receptors: 2156
      - Receptor Protein-Tyrosine Kinases: 6127
        trkA Receptor: 145
      - Peptide Receptors: 1208
        Growth Factor Receptors: 2687
        Nerve Growth Factor Receptors: 528
        trkA Receptor: 145
  - Intracellular Signaling Peptides and Proteins: 32
    - Protein-Tyrosine Kinases: 7827
      - Receptor Protein-Tyrosine Kinases: 6127
        trkA Receptor: 145

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Disease

Drug/Important Bio-Agent (IBA)